The application of cupric chloride dihydrate is regarded as a key substitute to reduce the use of antibiotics.  However, the European Commission pointed out that cupric chloride dihydrate has a serious impact on the environment. When fertilizer is applied to the land, a large amount of material is discharged into the field and ends there.  The Copper Chloride Dihydrate Manufacturers believes that this environmental impact is very debatable.

In some studies, the use of Basic Copper Sulphate is often related to the occurrence of methicillin-resistant Staphylococcus aureus (MRSA), which may carry zinc resistance genes.  In addition, the efficacy of some antibacterial agents has also been questioned by the Netherlands Institute of Veterinary Medicine.